Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats

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Science  27 Feb 1981:
Vol. 211, Issue 4485, pp. 957-959
DOI: 10.1126/science.7466371


Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.