Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances

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Science  06 Mar 1981:
Vol. 211, Issue 4486, pp. 1048-1051
DOI: 10.1126/science.6258226


Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.

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