Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness

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Science  06 Mar 1981:
Vol. 211, Issue 4486, pp. 1052-1054
DOI: 10.1126/science.7008197


Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells. The grafts were vascularized, did not evoke a homograft reaction, inhibited wound contraction, filled the wound space, and persisted.

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