Secondary structure of 16S ribosomal RNA

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Science  24 Apr 1981:
Vol. 212, Issue 4493, pp. 403-411
DOI: 10.1126/science.6163215


A secondary structure model for 16S ribosomal RNA which is based on available chemical, enzymatic, and comparative sequence data shows good agreement between constraints dictated by the model and a wide variety of experimental observations. The four major structural domains created by the base-pairing scheme correspond closely to RNA fragments isolated after nuclease digestion in the presence of bound ribosomal proteins. Functionally important sites appear to be located in unpaired regions and are phylogenetically highly conserved.