Lysosomal cathepsin B: correlation with metastatic potential

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Science  05 Jun 1981:
Vol. 212, Issue 4499, pp. 1151-1153
DOI: 10.1126/science.7233209


Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the tumor is unclear. The activity of the lysosomal proteinase cathepsin B is significantly elevated in a variant of the B16 melanoma with high metastatic potential. The cathepsin B activity is localized to the lysosomes of the tumor cells.