Autoantibodies from vasectomized guinea pigs inhibit fertilization in vitro

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Science  11 Sep 1981:
Vol. 213, Issue 4513, pp. 1267-1269
DOI: 10.1126/science.7268435


Immunoglobulin G and Fab antibodies were isolated from the serum of vasectomized guinea pigs, and the effects of the antibodies on fertilization in vitro were investigated. These antibodies had profound inhibitory effects on (i) sperm-to-sperm adhesion, (ii) the acrosome reaction, (iii) sperm-zona binding, and (iv) sperm-ovum fusion. This finding may explain certain cases of infertility after vasovasostomy in men.