Cellular aging: further evidence for the commitment theory

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Science  25 Sep 1981:
Vol. 213, Issue 4515, pp. 1505-1508
DOI: 10.1126/science.7280670


A large, transient reduction in the population size of human fibroblasts in early passages significantly increases the variability of the life-spans of cultures in comparison to control cultures, as predicted by the commitment theory of cellular aging. The theory also predicts that a constant population of noncycling cells will appear in the later part of the culture life-span. This was confirmed by labeling the cells in culture with tritiated thymidine.