The complement system of the nurse shark: hemolytic and comparative characteristics

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Science  30 Oct 1981:
Vol. 214, Issue 4520, pp. 566-569
DOI: 10.1126/science.7291995


The complement system of the nurse shark was investigated. Six functionally pure components were isolated from a single serum sample. Sequential reactions of the components with sensitized sheep erythrocytes resulted in membrane lesions indistinguishable from the "holes" caused by guinea pig complement.