Intraventricular calcitonin inhibits gastric acid secretion

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Science  06 Nov 1981:
Vol. 214, Issue 4521, pp. 671-673
DOI: 10.1126/science.7292006

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Parenteral and intracerebroventricular administration of calcitonin in rats resulted in the suppression of gastric acid secretion. This suppression also occurred in rats with insulin-induced hypoglycemia and after the administration of thyrotropin-releasing hormone. Intracerebroventricularly administered calcitonin was 1000 times more effective than parenterally administered calcitonin in suppressing gastric acid secretion. Calcitonin also inhibited the development of stress-induced ulcers in rats.

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