Dopamine receptor binding is increased in diabetic rats

See allHide authors and affiliations

Science  27 Nov 1981:
Vol. 214, Issue 4524, pp. 1031-1033
DOI: 10.1126/science.6458088


The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.

Stay Connected to Science