Reduction in oocyte number following prenatal exposure to a diet high in galactose

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Science  04 Dec 1981:
Vol. 214, Issue 4525, pp. 1145-1147
DOI: 10.1126/science.7302587


When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.

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