High levels of intracellular bombesin characterize human small-cell lung carcinoma

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Science  11 Dec 1981:
Vol. 214, Issue 4526, pp. 1246-1248
DOI: 10.1126/science.6272398


"Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.

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