Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells

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Science  18 Dec 1981:
Vol. 214, Issue 4527, pp. 1350-1353
DOI: 10.1126/science.7313693


The spontaneous rhythmic activity of aggregates of embryonic chick heart cells was perturbed by the injection of single current pulses and periodic trains of current pulses. The regular and irregular dynamics produced by periodic stimulation were predicted theoretically from a mathematical analysis of the response to single pulses. Period-doubling bifurcations, in which the period of a regular oscillation doubles, were predicted theoretically and observed experimentally.

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