Group B erythrocytes enzymatically converted to group O survive normally in A, B, and O individuals

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Science  08 Jan 1982:
Vol. 215, Issue 4529, pp. 168-170
DOI: 10.1126/science.6274021


With an alpha-galactosidase, B erythrocytes can be converted to blood group O under conditions that neither impair their viability in vitro nor affect their ability to survive normally after transfusion to individuals of groups O, A, and B. Such an approach has the potential for producing enzymatically converted group O cells for use in transfusion therapy. It should also be possible to convert A cells to group O by using the appropriate alpha-N-acetylgalactosaminidase.

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