Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys

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Science  05 Mar 1982:
Vol. 215, Issue 4537, pp. 1257-1260
DOI: 10.1126/science.7036347


Oscillations in the concentration of plasma glucose were found to reflect large fluctuations in hepatic glucose production. The fluctuations in glucose production were synchronous with fluctuations in the concentration of plasma insulin and glucagon. This synchrony suggests that hepatic pathways are entrained to the islet cycle with a minimal time delay.

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