Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies

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Science  19 Mar 1982:
Vol. 215, Issue 4539, pp. 1511-1513
DOI: 10.1126/science.7199757


High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates. Small tumors (200 to 300 milligrams) were visible without subtraction or enhancement 1 to 5 hours after injection of antibody. Chelate-derivitized monoclonal antibodies permit targeting of a broad spectrum of radioisotopes, including those that are optimum for agamma for gamma camera imaging or positron tomography, as well as those that are tumoricidal.