Rats self-administer nonrewarding brain stimulation to ameliorate aversion

See allHide authors and affiliations

Science  19 Mar 1982:
Vol. 215, Issue 4539, pp. 1516-1517
DOI: 10.1126/science.7063859


Hypothalamic stimulation in rats both reduces escape from noxious hindbrain stimulation and sustains self-administration only when hindbrain stimulation is inescapable. Self-administration reflects an aversion-ameliorative action of brain stimulation and not a positive reinforcement process. The psychophysical testing used is offered as a model for establishing the analgesic properties of brain stimulation.