Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction

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Science  07 May 1982:
Vol. 216, Issue 4546, pp. 640-642
DOI: 10.1126/science.7200262


Exposure of rats to phenobarbital during late prenatal development decreased the concentration of testosterone in plasma and the brain during the late fetal, early postnatal, pubertal, and adult periods, By decreasing the production of testosterone in the brain during the period of sexual differentiation, phenobarbital may lead to sexual dysfunction in later life.

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