Biotin enhances guanylate cyclase activity

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Science  18 Jun 1982:
Vol. 216, Issue 4552, pp. 1329-1330
DOI: 10.1126/science.6123152


Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.

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