Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells

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Science  09 Jul 1982:
Vol. 217, Issue 4555, pp. 157-158
DOI: 10.1126/science.6806903


Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.