Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal

See allHide authors and affiliations

Science  06 Aug 1982:
Vol. 217, Issue 4559, pp. 535-537
DOI: 10.1126/science.7089579


When the Y chromosome from Mus poschiavinus (YPOS) is transferred onto the C57BL/6J genome, XY individuals develop as females with two ovaries, or as hermaphrodites. No XY individual develops normal testes. Although C57BL/6J-YPOS XY females are rarely fertile, most hermaphrodites with normal male genitalia sire offspring. Thus, the Mus poschiavinus Y chromosome carries a form of the Y-linked testis-determining locus different from that present in the C57BL/6J inbred strain. This gene interacts abnormally with autosomal or X-linked testis-determining loci of the CS7BL/6J genome to prevent normal testicular differentiation. Divergence of the Y-linked testis-determining gene may be involved in mammalian speciation.

Stay Connected to Science