Cellular transforming genes

See allHide authors and affiliations

Science  27 Aug 1982:
Vol. 217, Issue 4562, pp. 801-806
DOI: 10.1126/science.6285471


Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.

Stay Connected to Science