Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury

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Science  27 Aug 1982:
Vol. 217, Issue 4562, pp. 855-857
DOI: 10.1126/science.7100929


Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate and enduring acceleration of recovery was produced by a single dose of d-amphetamine given 24 hours after injury. This effect was blocked by haloperidol or by restraining the animals for 8 hours beginning immediately after amphetamine administration. A single dose of haloperidol given 24 hours after injury markedly slowed recovery. This effect was also blocked by restraining the animals.

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