Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets

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Science  17 Sep 1982:
Vol. 217, Issue 4565, pp. 1155-1156
DOI: 10.1126/science.6126003


After monolayer cultures of rat islets were exposed to [125I]insulin,[125I]glucagon, and [125I]tyrosinyl somatostatin, specific autoradiographic grains associated with each radioactively labeled ligand were found on B, A, and D cells.The density of labeling of the B, A, and D cells with each labeled ligand correlated well with the known actions of the three hormones on each of the islet cells.

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