Transmethylation of phosphatidylethanolamine: an initial event in embryonic chicken lens fiber cell differentiation

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Science  24 Sep 1982:
Vol. 217, Issue 4566, pp. 1265-1267
DOI: 10.1126/science.7112130


Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiber formation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells.

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