Naloxone antagonism of the thermoregulatory effects of phencyclidine

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Science  24 Sep 1982:
Vol. 217, Issue 4566, pp. 1272-1273
DOI: 10.1126/science.6287581


Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.

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