Pathfinding by Peripheral Pioneer Neurons in Grasshoppers

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Science  10 Dec 1982:
Vol. 218, Issue 4577, pp. 1082-1088
DOI: 10.1126/science.218.4577.1082


Grasshopper neurons accurately project axons across long distances between peripheral structures and the central nervous system. Nerve-trunk pathways followed by these axons are established early in embryogenesis by pioneer neurons. Growth cones from the first pioneers navigate along a chain of cells to the CNS. The placement of these cells may constitute the initial guidance mechanism underlying long-distance pathfinding.

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