Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells

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Science  25 Feb 1983:
Vol. 219, Issue 4587, pp. 987-988
DOI: 10.1126/science.6297010


Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent infection.

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