An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons

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Science  11 Mar 1983:
Vol. 219, Issue 4589, pp. 1230-1232
DOI: 10.1126/science.6131536


cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.

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