Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence

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Science  27 May 1983:
Vol. 220, Issue 4600, pp. 963-965
DOI: 10.1126/science.6844921


Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.