Neural crest cells contribute to normal aorticopulmonary septation

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Science  03 Jun 1983:
Vol. 220, Issue 4601, pp. 1059-1061
DOI: 10.1126/science.6844926


By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

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