Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans

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Science  17 Jun 1983:
Vol. 220, Issue 4603, pp. 1277-1279
DOI: 10.1126/science.6857247


Mutations in two nonessential genes specifically block the phagocytosis of cells programmed to die during development. With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths. Instead, these deaths appear to occur by cell suicide.

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