Hypothalamic gamma-aminobutyric acid neurons project to the neocortex

See allHide authors and affiliations

Science  17 Jun 1983:
Vol. 220, Issue 4603, pp. 1309-1311
DOI: 10.1126/science.6857253


Three groups of gamma-aminobutyric acid--containing neurons were found in the mammillary region of the posterior hypothalamus. The groups correspond to the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Many cells in these nuclei were retrogradely labeled with fast blue after the injection of this fluorescent dye into the neocortex. Immunohistochemical experiments showed that these same neurons also contained the gamma-aminobutyric acid-synthesizing enzyme glutamate decarboxylase. These results provide morphological evidence for a gamma-aminobutyric acid pathway arising in magnocellular neurons of the posterior hypothalamus and innervating the neocortex.

Stay Connected to Science