Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons

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Science  26 Aug 1983:
Vol. 221, Issue 4613, pp. 875-877
DOI: 10.1126/science.6603658


Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations greater than 250 nanomoles per liter also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel calcium-dependent process.