Lewy bodies of Parkinson's disease contain neurofilament antigens

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Science  09 Sep 1983:
Vol. 221, Issue 4615, pp. 1082-1084
DOI: 10.1126/science.6308771


The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.