Altered activity patterns during development reduce neural tuning

See allHide authors and affiliations

Science  16 Sep 1983:
Vol. 221, Issue 4616, pp. 1183-1185
DOI: 10.1126/science.6612332


Neonatal mice were reared in an acoustic environment that repetitively entrained activity in a large proportion of primary auditory afferents during the period when the frequency tuning of auditory neurons normally develops. The tuning curves obtained from these mice were significantly broader than those of normally reared mice of the same age. This suggests that the normal frequency tuning of neurons was prevented or delayed by synchronizing the pattern of activity imposed on the auditory pathway.

Stay Connected to Science