Neuromagnetic evidence of spatially distributed sources underlying epileptiform spikes in the human brain

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Science  20 Jan 1984:
Vol. 223, Issue 4633, pp. 293-296
DOI: 10.1126/science.6422552


Neuromagnetic measurements were performed on 17 subjects with focal seizure disorders. In all of the subjects, the interictal spike in the scalp electroencephalogram was associated with an orderly extracranial magnetic field pattern. In eight of these subjects, multiple current sources underlay the magnetic spike complex. The multiple sources within a given subject displayed a fixed chronological sequence of discharge, demonstrating a high degree of spatial and temporal organization within the interictal focus.

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