Microdifferential holography and the polysarcomeric unit of activation of skeletal muscle

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Science  24 Feb 1984:
Vol. 223, Issue 4638, pp. 822-825
DOI: 10.1126/science.6695184


Unbalanced holographic difference images of contracting skeletal muscle fibers reveal that activation affects the amplitude of the light scattered by individual myofibrils. The results suggest that the unit of activation is not the sarcomeric structural unit, but a monomyofibrillar segment containing 20 to 40 contiguous sarcomeres.