T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells

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Science  09 Mar 1984:
Vol. 223, Issue 4640, pp. 1086-1087
DOI: 10.1126/science.6320374


Activated mature T cells require T-cell growth factor (TCGF) for continuous proliferation. However, many mature T cells infected with human T-cell leukemia-lymphoma virus grow independently of exogenously added TCGF. It is now reported that cells infected with this virus also lack detectable TCGF messenger RNA (less than one copy per cell) and thus do not produce their own growth factor. The results apparently rule out an autostimulation mechanism of growth control.