Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm

See allHide authors and affiliations

Science  30 Mar 1984:
Vol. 223, Issue 4643, pp. 1435-1437
DOI: 10.1126/science.6701530


Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.