Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning

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Science  11 May 1984:
Vol. 224, Issue 4649, pp. 627-630
DOI: 10.1126/science.6324350


Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naive rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.