Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral vasodilation

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Science  25 May 1984:
Vol. 224, Issue 4651, pp. 898-901
DOI: 10.1126/science.6719122


In vitro pharmacological studies demonstrated that exogenously applied vasoactive intestinal polypeptide (VIP) relaxes the smooth muscle cells of cat cerebral arteries, whereas substance P constricts them. Ultrastructural-immunocytochemical techniques show that a VIP-like substance is present in the large granular vesicles of nonsympathetic nerve axons and terminals in the cerebral arterial walls. These results provide strong evidence in favor of the hypothesis that a VIP-like substance is the transmitter for vasodilation in cerebral blood vessels.

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