Saccharomyces cerevisiae produces a yeast substance that exhibits estrogenic activity in mammalian systems

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Science  08 Jun 1984:
Vol. 224, Issue 4653, pp. 1109-1111
DOI: 10.1126/science.6372097


Partially purified lipid extracts of Saccharomyces cerevisiae contain a substance that displaces tritiated estradiol from rat uterine cytosol estrogen receptors. The yeast product induces estrogenic bioresponses in mammalian systems as measured by induction of progesterone receptors in cultured MCF-7 human breast cancer cells and by a uterotrophic response and progesterone receptor induction after administration to ovariectomized mice. The findings raise the possibility that bakers' yeast may be a source of environmental estrogens.