Organ-specific adhesion of metastatic tumor cells in vitro

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Science  08 Jun 1984:
Vol. 224, Issue 4653, pp. 1113-1115
DOI: 10.1126/science.6372098


Binding of tumor cells to cryostat sections of host organs was studied. B16-F10 melanoma cells and reticulum cell sarcoma cells demonstrated an organ specificity in their binding in vitro that reflected the organ specificity of their metastatic distribution 25 days after intravenous injection. These results provide evidence for specific binding of tumor cells to the tissues that they selectively colonize in vivo.