Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

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Science  14 Sep 1984:
Vol. 225, Issue 4667, pp. 1168-1170
DOI: 10.1126/science.6474172


Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.

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