21 September 1984
Vol 225, Issue 4668

About The Cover

Horizontal section through a rat brain showing immunocytochemical localization (blue stain) of a neuronal phosphoprotein. This protein, DARPP-32, is enriched in neurons of the basal ganglia, which are involved in the pathophysiology of Huntington's disease and Parkinson's disease. Many such brain phosphoproteins have been found which play important roles in the function of nerve cells. See page 1357. [Charles C. Ouimet, Hugh C. Hemmings, Jr., and Paul Greengard, The Rockefeller University, New York 10021]