Prophenoloxidase Activation: Nonself Recognition and Cell Cooperation in Insect Immunity

See allHide authors and affiliations

Science  02 Nov 1984:
Vol. 226, Issue 4674, pp. 557-559
DOI: 10.1126/science.226.4674.557


The mechanism of nonself recognition by the immune system of insects is unknown. In this report the activation of the prophenoloxidase system in the wax moth Galleria mellonella by a microbial product is shown to enhance the recognition of nonself material. These results explain previous observations of the interaction of two different blood cell populations in the cellular defense reactions of insects.