Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons

See allHide authors and affiliations

Science  02 Nov 1984:
Vol. 226, Issue 4674, pp. 561-564
DOI: 10.1126/science.6093252


The motile activity of growth cones of specific identified neurons is inhibited by the neurotransmitter serotonin, although other identified neurons are unaffected. As a consequence, affected neurons are unable to form electrical synapses, whereas other neurons whose growth is unaffected can still interconnect. This result demonstrates that neurotransmitters can play a prominent role in regulating neuronal architecture and connectivity in addition to their classical role in neurotransmission.