Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor

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Science  09 Nov 1984:
Vol. 226, Issue 4675, pp. 705-707
DOI: 10.1126/science.6093254

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Purified growth inhibitor from BSC-1 cells and type beta transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type beta transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions.

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