Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

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Science  30 Nov 1984:
Vol. 226, Issue 4678, pp. 1077-1080
DOI: 10.1126/science.6093260


Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.

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